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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) of more than 27, so long as they also experience weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to smoking cessation treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and also have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercising. Results from a medical trial that enrolled patients without diabetes established that patients had the average weight loss of 4.1% instead of participants have been given placebos) throughout a 12- month period, while an outside study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to lose weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight loss and the people who go through it one should err assisting caution and permit the FDA do its job and demand some research be done so your public recognizes the side effects and risks of the medications before we bring them. Keep in mind that drug companies come in business to generate money and that they would say almost anything to keep people on his or her medications.

Researchers found out that participants using this drug for the year, dropped a few pounds within a month and have kept the body weight off through the 56 weeks of the study. Contrave can be a combination with the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs which are made up of multiple active ingredient, which can make them more efficient and safer.

Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is now popular may be the fact that as of right now there are not any long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug also can raise hypertension and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must not be used in patients with uncontrolled high hypertension, along with by you aren't heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

Other people who must avoid using Contrave are patients suffering from bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave should not be prescribed for girls who are pregnant or looking to become pregnant.